Prothrombinex‐VF use in warfarin reversal and other indications

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Prothrombinex-VF use in warfarin reversal and other indications.

OBJECTIVE To assess the use of Prothrombinex-VF powder for injection (PTX-VF) at Royal Perth Hospital and analyse the efficacy and safety profile of PTX-VF. DESIGN, SETTING AND PATIENTS A prospective observational audit of PTX-VF use, conducted by reviewing medical records and laboratory and imaging results for all patients prescribed PTX-VF from 1 November 2009 to 1 May 2010. MAIN OUTCOME ...

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Warfarin prevalence, indications for use and haemorrhagic events.

Warfarin, the standard oral anticoagulant drug used in Ireland, is a widely prescribed medication, particularly in the elderly. A HSE Mid-Western Area wide audit was undertaken over a 12-month period to examine the prevalence and indications for warfarin use and haemorrhagic complications associated with the drug. Every patient receiving warfarin therapy over a 13-week period was included (2564...

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Prothrombin complex concentrates in warfarin anticoagulation reversal

Anticoagulation is very effective for primary and secondary prevention of thromboembolic events. However, questions persist about the risks and management of over-anticoagulation. The annual incidence of major bleeding in trials and cohort studies has been reported to be between 1.1% and 2.3% in patients treated with warfarin to achieve an international normalized ratio (INR) of 2.0 to 3.0. The...

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Reversal of warfarin in life-threatening bleeding.

To the Editor—I read with interest the article “The benefit of prothrombin complex concentrate in decreasing neurological deterioration in patients with warfarin-associated intracerebral haemorrhage” by Fong et al in the December 2014 issue of the Hong Kong Medical Journal.1 The Australian guidelines for warfarin reversal quoted in the article were outdated.2 The most recent Australian guidelin...

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Reversal of warfarin: case-based practice recommendations.

Case Presentation: A 74-year-old woman presents to the emergency department with bruising. She takes warfarin for atrial fibrillation. She has recently begun taking trimethoprim/ sulfamethoxazole. Her international normalized ratio (INR) is reported as 8.6. Supratherapeutic INR values are common in warfarin-treated patients. In this case, the antibiotic is the likely cause, but it is not unusua...

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ژورنال

عنوان ژورنال: Medical Journal of Australia

سال: 2012

ISSN: 0025-729X,1326-5377

DOI: 10.5694/mja11.10797